Publications

For a full list of publications, check out PubMed or Google Scholar!

2025

Conference Abstracts

Colicchio CJ, Connizzo BK. Cellular Uptake of Sex Steroid Hormones is Dependent on Mechanical Loading and Pretreatment. (Submitted to BMES Annual Meeting 2025)
Stowe EJ, Connizzo BK. Senescent Cells Disrupt ECM Remodeling In Response To Exercise. (89th CSHL Symposium: Senescence & Aging)
Lim MT, Aggouras AN, Eyckmans J, Connizzo BK. Aging Alters the Intrinsic Ability of Tendons to Clear Damaged Matrix Following Microdamage. (ORS 2025)
Sander AM, Connizzo BK. Simulated Estrous Cycle Better Maintains ECM Homeostasis in Female Mice Than Sustained Hormone Delivery. (ORS 2025)
Stowe EJ, Grover Y, Connizzo BK. Exercise and Disuse Initiate Adaptive ECM Remodeling to Shift Tendon Mechano-Homeostasis. (ORS 2025)
Kalčo H, Divieti Pajevic P, Thompson LV, Connizzo BK. Inflammatory Crosstalk Between Rotator Cuff Tissues is Altered with Age and Biological Sex. (ORS 2025)
Aggouras AN, Eyckmans J, Connizzo BK. Injury Size Affects the Timing and Mechanism of Microdamage Clearance in Tendons. (ORS 2025)
Aggouras AN, Eyckmans J, Connizzo BK. Regulation of Immune Signaling in MRL/MpJ Local Cell-Mediated Microdamage Repair. (ORS 2025)

Manuscripts

Kalčo H, Divieti Pajevic P, Thompson LV, Connizzo BK. Inflammatory Crosstalk Between Rotator Cuff Tissues is Altered with Age and Sex. bioRxiv 2025.06.11.658924. [Preprint]
Aggouras AN, Lim MT, Eyckmans J, Connizzo BK. Intrinsic Repair Capacity of Resident Tendon Cells is Dependent on Hole Size in an Ex Vivo Model of Laser-Induced Microdamage. bioRxiv 2025.05.29.656650. [Preprint]
Sander AM & Connizzo BK. Estrogen and progesterone exhibit distinct yet coordinated roles in the regulation of tendon extracellular matrix remodeling. J Orthop Res 2025; 1–11 [Open Access]
Mlawer SM. Pinto FR, Sikes KJ, & Connizzo BK. Coordination of Glucose and Glutamine in Tendon is Lost in Aging. JOR. 2025 May 19 [Pubmed]

2024

Conference Abstracts

Kalco H, Divieti Pajevic P, Thompson LV, Connizzo BK. Downhill Running Induces Anti-Inflammatory Signaling in Bone and Tendon. (ASBMR 2024)
Sander AM, Connizzo BK. The Impacts of Estrogen and Progesterone on Tendon Extracellular Matrix Remodeling in Female Mice Are Strain-Dependent. (MS Competition Winner, SB3C2024)
Mlawer SM, Connizzo BK. Aged Tendons Have A Higher Strain Threshold For Stimulation From Dynamic Compression Than Young Tendons. (SB3C2024)
Kalco H, Connizzo BK. Age-related Differences in The Response To Tumor Necrosis Factor Alpha (TNF-alpha). (ORS 2024)
Aggouras AN, Connizzo BK. Higher Efficiency Microdamage Clearance In MRL/MpJ Tendon Following Laser Ablation. (ORS 2024)
Sander AM, Connizzo BK. Tendon Extracellular Matrix Remodeling Is Dependent On Sex Hormone Signaling. (ORS 2024)
Stowe EJ. Aged Tendons Exhibit Muted Remodeling Responses to Varying Levels of Cyclic Tensile Strain. (ORS 2024)
Lim MT, Aggouras AN, Eyckmans J, Connizzo BK. Aging Alters the Intrinsic Ability of Tendons to Clear Damaged Matrix Following Microdamage.

Manuscripts

Mlawer SM. Pinto FR, Sikes KJ, & Connizzo BK. Coordination of Glucose and Glutamine in Tendon is Lost in Aging. bioRxiv. 2024.12.19.629426 [Preprint]
Aggouras AN, Stowe EJ, Mlawer SJ, & Connizzo BK. Aged Tendons Exhibit Altered Mechanisms of Strain-Dependent Extracellular Matrix Remodeling. J Biomech Eng. 2024 Apr 6:1-41. [PubMed]
Almier N, Leibowitz K, Gower AC, Keller MR, Connizzo BK, Roh DS, Alani RM, Collard M. Targeting the Epigenome Reduces Keloid Fibroblast Cell Proliferation, Migration and Invasion. J Invest Dermatol. 2024 Jul 13:S0022-202X(24)01872-4. [PubMed]
Stowe EJ, Keller MR, & Connizzo BK. Cellular Senescence Impairs Tendon Extracellular Matrix Remodeling in Response to Mechanical Unloading. Aging Cell. 2024 [PubMed]

2023

Conference Abstracts

Stowe EJ, Connizzo BK. Senescence Contributes to Death Resistance of Aged Tenocytes in a Model of Secondary Joint Damage. (ORS 2023)
Aggouras AN, Connizzo BK. Earlier Proteoglycan Turnover Promotes Higher Efficiency Matrix Remodeling in MRL/MpJ Tendons. (ORS 2023)
Mlawer SJ, Connizzo BK. Differential Effect of Acute Compressive Injury on Young and Aged Tendons. (ORS 2023)
Stowe EJ, Connizzo BK. Cellular Senescence Suppresses ECM Synthesis in Response to Mechanical Unloading in Tendon Explants. (SB3C 2023)
Aggouras AN, Lim MT, Eyckmans J, Connizzo BK. A Novel Laser Ablation Model for Studying Local Microdamage Repair in Live Tendon Explants. (SB3C 2023, Ph.D. Student Paper Competition Runner-Up)
Aggouras AN, Connizzo BK. Cyclic Strain Induces Matrix Turnover to Better Maintain Tendon Composition in Explant Culture. (SB3C 2023)

Manuscripts

Aggouras AN, Connizzo BK. Earlier proteoglycan turnover promotes higher efficiency matrix remodeling in MRL/MpJ tendons. J Orthop Res. 2023;1‐12. [PubMed]
Mlawer SJ, Frank EH, Connizzo BK. Aged tendons lack adaptive response to acute compressive injury. J Orthop Res. 2023; 1-12. [PubMed]

2022

Conference Abstracts

Aggouras AN, Connizzo BK. MRL/MpJ Tendon Explants Maintain Greater Matrix Synthesis in Response to Stress Deprivation. (ORS 2022)
Stowe EJ, Connizzo BK. Induction and Characterization of Cellular Senescence in Tendon Explants. (ORS 2022)
Pinto FR, Aggouras AA, Connizzo BK. The Role of Glutamine Supplementation in Protein Synthesis of Murine Tendon Explants. (BMES 2022)

2021

Conference Abstracts

Larson EL, Grodzinsky AJ, Connizzo BK. The Effects of High Glucose Levels and Medium Supplementation on Tendon Explant Homeostasis are Tissue-Dependent. (ORS 2021).
Connizzo BK, Grodzinsky AJ. Static Mechanical Stimulus is More Beneficial for Aged Tendons in Preventing Disuse-Related Degeneration In Vitro. (ORS 2021)

Manuscripts

Siadat SM, Zamboulis DE, Thorpe CT, Ruberti JW, Connizzo BK. Tendon Extracellular Matrix Assembly, Maintenance, and Dysregulation Throughout Life. Adv Exp Med Biol. 2021 Nov; 1348:45-103. [PubMed]
Connizzo BK, Sun L, Lacin N, Gendelman A, Solomonov I, Sagi I, Grodzinsky AJ, Naveh GRS. Non-Uniformity in Periodontal Ligament: Mechanics and Matrix Composition. J Dent Res. 2021 Feb;100(2):179-186. [PubMed] [YouTube]
Izu Y, Adams SM, Connizzo BK, Beason DP, Soslowsky LJ, Koch M, Birk DE. Collagen XII Mediated Cellular and Extracellular Mechanisms Regulate Establishment of Tendon Structure and Function. Matrix Biol. 2021 Jan; 95:52-67. [PubMed]

2020

Conference Abstracts

Connizzo BK, Grodzinsky AJ. Tendon Inflammatory Responses Are Altered with Age in an In Vitro Rotator Cuff Model of Secondary Joint Damage. (ORS 2020)

Manuscripts

Connizzo BK & Naveh GRS. In Situ AFM-Based Nanoscale Rheology Reveals Regional Non-Uniformity in Viscoporoelastic Mechanical Behavior of the Murine Periodontal Ligament. J Biomech. 2020 Oct 9;111:109996 [PubMed] [YouTube]
Connizzo BK, Grodzinsky AJ. Low-Dose Administration of Dexamethasone is Beneficial in Preventing Secondary Tendon Damage in a Stress-Deprived Joint Injury Explant Model. J Orthop Res. 2020 Jan;38(1):139-149. [PubMed]
Connizzo BK, Piet JM, Shefelbine SJ, Grodzinsky AJ. Age-Associated Changes in the Response of Tendon Explants to Stress Deprivation is Sex-Dependent. Connect Tissue Res. 2020 Jan;61(1):48-62. [PubMed]

2019

Conference Abstracts

Connizzo BK, Drago JM, Frank EH, Grodzinsky AJ. Static Tensile Strain Does Not Alter Tendon Response To Joint Inflammation In A Murine Explant Model. (BMES 2019)
Connizzo BK, Grodzinsky AJ. Low-Dose Dexamethasone Prevents Cytokine-Induced Cell Death and Injury-Like Response in Both Flexor Tendon-Only and Rotator Cuff Bone-Tendon-Muscle In Vitro Explant Models. (ORS 2019)

2018

Conference Abstracts

Connizzo BK, Grodzinsky AJ. Bone and Muscle Degradation Impact Tendon Viability in a Murine Rotator Cuff Explant Organ Culture Model. (ORS 2018)
Rodriguez AB, Shetye SS, Connizzo BK, Huegel J, Birk DE, Soslowsky LJ. Reduced Activity in Collagen V Deficient Mice Alters Bone Morphology. (ORS 2018)

Manuscripts

Connizzo BK, Grodzinsky AJ. Release of Pro-Inflammatory Cytokines from Muscle and Bone Causes Tenocyte Death in a Novel Rotator Cuff In Vitro Explant Culture Model. Conn Tissue Res. 2018 Sep;59(5):423-436. [PubMed]
Oftadeh R, Connizzo BK, Nia HT, Ortiz C, Grodzinsky AJ. Poroviscoelasticity of Biological Connective Tissues at the Nanoscale: Application to Tendon and Skin Biophysics. Acta Biomater. 2018 Apr 1;70:249-259. [PubMed]
Connizzo BK, Grodzinsky AJ. Multiscale Poroviscoelastic Compressive Properties of Mouse Supraspinatus Tendons Are Altered in Young and Aged Mice. J Biomech Eng. 2018 May 1;140(5). [PubMed]

2017

Conference Abstracts

Connizzo BK, Zlotnick HM, Drago JM, Grodzinsky AJ. Development and Characterization of an In Vitro Tendon-Muscle-Bone Explant Culture. (BMES 2017)
Connizzo BK, Grodzinsky AJ. Aged Supraspinatus Tendons Have Altered Dynamic Compressive and Poroelastic Properties. (SB3C 2017)
Connizzo BK, Grodzinsky AJ. Dynamic Compressive Mechanical Properties of Supraspinatus Tendons Are Altered in Aged Mice. (ORS 2017)

Manuscripts

Barnum CE, Fey JL, Connizzo BK, Shetye SS, Elovitz MA, Soslowsky LJ. Tensile Mechanical Properties and Dynamic Collagen Fiber Re-Alignment of the Murine Cervix are Dramatically Altered Throughout Pregnancy. J Biomech Eng. 2017 Jun 1;139(6). [PubMed]
Johnston JM, Connizzo BK, Shetye SS, Robinson KA, Huegel J, Rodriguez AB, Sun M, Adams SM, Birk DE, Soslowsky LJ. Collagen V Haploinsufficiency in a Murine Model of Classic Ehlers-Danlos Syndrome is Associated with Deficient Structural and Mechanical Healing in Tendons. J Orthop Res. 2017 Dec;35(12):2707-2715. [PubMed]
Connizzo BK, Grodzinsky AJ. Tendon Exhibits Complex Poroelastic Behavior at the Nanoscale as Revealed by High-Frequency AFM-Based Rheology. J Biomech, 2017 Mar 21;54:11-18. [PubMed]

2016

Conference Abstracts

Connizzo BK, Adams SM, Adams TH, Jawad AF, Birk DE, Soslowsky LJ. Multiscale Regression Modeling in Mouse Supraspinatus Tendons Reveals Regional Contribution of Dynamic Processes to Structure-Function Relationships. (SB3C 2016)
Connizzo BK, Adams S, Birk DE, Soslowsky LJ. Structure and Composition in Tendons with Altered Collagen V Expression are Location-Dependent. (ORS 2016)
Connizzo BK, Han L, Birk DE, Soslowsky LJ. Collagen V-Deficient Tendons Exhibit Altered Dynamic Mechanical Behavior at Multiple Hierarchical Scales. (ORS 2016)

Manuscripts

Connizzo BK, Adams SM, Adams TH, Birk DE, Soslowsky LJ. Collagen V Expression is Crucial for Regional Development of Supraspinatus Tendon. J Orthop Res. 2016 Dec;34(12):2154-2161. [PubMed]
Connizzo BK, Adams SM, Adams TH, Jawad AF, Birk DE, Soslowsky LJ. Multiscale Regression Modeling in Mouse Supraspinatus Tendons Reveals That Dynamic Processes Act as Mediators in Structure-Function Relationships. J Biomech 2016 Jun 14;49(9):1649-1657. [PubMed]
Connizzo BK, Han L, Birk DE, Soslowsky LJ. Collagen V-Heterozygous and -Null Supraspinatus Tendons Exhibit Altered Dynamic Mechanical Behavior at Multiple Hierarchical Scales. Interface Focus 2016 Feb 6;6(1):20150043. [PubMed]
Tucker JJ, Riggin CN, Connizzo BK, Mauck RL, Steinberg DR, Kuntz AF, Soslowsky LJ, Bernstein J. Effect of Overuse-Induced Tendinopathy on Tendon Healing in a Rat Supraspinatus Repair Model. J Orthop Res. 2016 Jan;34(1):161-6. [PubMed]

2015

Conference Abstracts

Connizzo BK, Birk DE, Soslowsky LJ. The Dynamic Mechanical Response is Severely Altered in Collagen V Deficient Mouse Supraspinatus Tendons. (ASME SBC 2015)
Connizzo BK, Fried JH, Sun M, Birk DE, Soslowsky LJ. Critical Regulatory Role for Collagen V in Establishing the Unique Mechanical Properties of Joint Stabilizing Tendons. (ORS 2015)
Tucker JJ, Connizzo BK, Riggin CN, Mauck RL, Steinberg DR, Kuntz AF, Soslowsky LJ, Bernstein J. Tendon Healing in a Supraspinatus Tear and Repair Rat Model is not Altered by Overuse-Induced Tendinopathy. (ORS 2015)

Manuscripts

Ahmadzadeh H, Freedman BR, Connizzo BK, Soslowsky LJ, Shenoy VB. Micromechanical poroelastic finite element and shear-lag models of tendon predict large strain dependent Poisson's ratios and fluid expulsion under tensile loading. Acta Biomater. 2015 Aug;22:83-91. [PubMed]
Connizzo BK, Freedman BR, Fried JH, Sun M, Birk DE, Soslowsky LJ. Regulatory Role for Collagen V in Establishing the Unique Mechanical Properties of Tendons and Ligaments is Tissue-Dependent. J Orthop Res. 2015 Jun;33(6):882-8. [PubMed]
Sun M, Connizzo BK, Adams SM, Freedman BR, Schweitzer R, Wenstrup RJ, Soslowsky LJ, Birk DE. Targeted Deletion of Collagen V in Tendons and Ligaments Results in a Classic Ehlers-Danlos Syndrome Joint Phenotype. J Am Pathol. 2015 May;185(5):1436-47. [PubMed]

2014

Conference Abstracts

Sun M, Connizzo BK, Adams SM, Freedman BR, Johnson R, Schweitzer R, Soslowsky LJ, Birk DE. A Tendon-Specific Collagen V-Null Mouse Model Demonstrates A Joint Phenotype Characteristic of Classic Ehlers-Danlos Syndrome. (ASMB 2014)
Connizzo BK, Sarver JJ, Han L, Soslowsky LJ. In Situ Fibril Stretch in Mouse Supraspinatus Tendons is Location-Dependent. (WCB 2014)
Connizzo BK, Freedman BR, Sun M, Birk DE, Soslowsky LJ. Collagen V Null Mice Have Decreased ACL Mechanical Properties and Altered Fibril Morphology. (ORS 2014)
Connizzo BK, Feeney E, Iozzo RV, Birk DE, Soslowsky LJ. In Situ Collagen Crimp is Altered with Age and Proteoglycan Deficiency in Mouse Supraspinatus Tendons. (ORS 2014)

Manuscripts

Connizzo BK, Sarver JJ, Han L, Soslowsky LJ. In Situ Fibril Stretch and Sliding is Location-Dependent in Mouse Supraspinatus Tendons. J Biomech 2014 Dec 18;47(16):3794-8. [PubMed]
Connizzo BK, Bhatt PR, Liechty KW, Soslowky LJ. Diabetes Alters Mechanical Properties and Collagen Fiber Re-Alignment in Multiple Mouse Tendons. Ann Biomed Eng 2014 Sep;42(9):1880-8. [PubMed]
Connizzo BK, Yannascoli SM, Tucker JJ, Caro AC, Riggin CN, Mauck RL, Soslowsky LJ, Steinberg DR, Bernstein J. The Detrimental Effects of Systemic Ibuprofen Delivery on Tendon Healing Are Time-Dependent. Clin Orthop Relat Res. 2014 Aug;472(8):2433-9. [PubMed]

2013

Conference Abstracts

Connizzo BK, Birk DE, Iozzo RV, Soslowsky LJ. Effects of Decorin and Biglycan on Re-Alignment and Mechanical Properties of Aging Supraspinatus Tendons. (ORS 2013)

Manuscripts

Ahmadzadeh H, Connizzo BK, Freedman BR, Soslowsky LJ, Shenoy VB. Determining the contribution of glycosaminoglycans to tendon mechanical properties with a modified shear-lag model. J Biomech. 2013 Sep 27;46(14):2497-503. [PubMed]
Connizzo BK, Sarver JJ, Iozzo RV, Birk DE, Soslowsky LJ. Effect of age and proteoglycan deficiency on collagen fiber re-alignment and mechanical properties in mouse supraspinatus tendon. J Biomech Eng. 2013 Feb;135(2):021019. [PubMed]
Connizzo BK, Yannascoli SM, Soslowsky LJ. Structure-function relationships of postnatal tendon development: A parallel to healing. Matrix Biol. 2013 Mar 11;32(2):106-16. [PubMed]

2012

Conference Abstracts

Connizzo BK, Liechty KW, Soslowsky LJ. Altered Mechanical Properties and Fiber Re-Alignment in db/db Mouse Supraspinatus and Achilles Tendons. (SBC 2012)
Miller KS, Connizzo BK, Feeney E, Soslowsky LJ. Collagen Fiber Re-Alignment and Mechanical Properties in a Mouse Supraspinatus Tendon Model: Examining Changes with Age and Location. (ASME SBC 2012)
Beason DP, Connizzo BK, Dourte LM, Edelstein L, Tucker JJ, Liu SS, Mauck RL, Soslowsky LJ, Steinberg DR, Bernstein J. Fiber-Aligned Polymer Scaffolds for Rotator Cuff Repair in a Rat Model. (ORS 2012)
Miller KS, Connizzo BK, Tucker JJ, Feeney E, Trasolini NR, Soslowsky LJ. Local Differences in Collagen Fiber Crimp Throughout Mechanical Testing in a Mouse Supraspinatus Tendon Model. (ORS 2012)
Miller KS, Connizzo BK, Tucker JJ, Soslowsky LJ. Collagen Fiber Re-Alignment in a Neonatal Developmental Mouse Supraspinatus Tendon Model. (ORS 2012)

Manuscripts

Miller KS, Connizzo BK, Feeney E, Soslowsky LJ: Characterizing Local Collagen Fiber Re-Alignment and Crimp Behavior Throughout Mechanical Testing in a Mature Mouse Supraspinatus Tendon Model. J Biomech. 2012 Aug 9;45(12):2061-5. [PubMed]
Miller KS, Connizzo BK, Feeney E, Tucker JJ, Soslowsky LJ: Examining differences in local Collagen Fiber Crimp Frequency Throughout Mechanical Testing in a Developmental Mouse Supraspinatus Tendon Model. J Biomech Eng. 2012 Apr;134(4):041004. [PubMed]
Miller KS, Edelstein L, Connizzo BK, Soslowsky LJ: Effect of Preconditioning and Stress Relaxation on Local Collagen Fiber Re-Alignment: Inhomogeneous Properties of Rat Supraspinatus Tendon. J Biomech Eng. 2012 Mar;134(3):031007. [PubMed]
Beason DP, Connizzo BK, Dourte LM, Edelstein L, Tucker JJ, Liu SS, Mauck RL, Soslowsky LJ, Steinberg DR, Bernstein J. Fiber-Aligned Polymer Scaffolds for Rotator Cuff Repair in a Rat Model. Journal of Shoulder and Elbow Surgery. 2012 Feb;21(2):245-50. [PubMed]
Miller KS, Connizzo BK, Soslowsky LJ: Collagen Fiber Re-Alignment in a Neonatal Developmental Mouse Supraspinatus Tendon Model. Ann Biomed Eng. 2012 May;40(5):1102-10. [PubMed]

2011

Conference Abstracts

Mikic B, Connizzo B, McGrath M, Shea J, Bierwert L: The Effect of Myostatin Deficiency on Murine Tendon Material Behavior. (ORS 2011)